ERα17p

• Description :

  ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models[1][2][3].

• CAS Number :

  [938077-77-1]

• Product Name Alternative :

  ERα (295-311)

• UNSPSC :

  12352209

• Target :

  Apoptosis

• Type :

  Peptides

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/erα17p.html

• Smiles :

  O=C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]1NCCC1

• Molecular Formula :

  C84H154N24O23S

• Molecular Weight :

  1900.33

• References & Citations :

  [1]Kampa M, et al., ERα17p, an ERα P295 -T311 fragment, modifies the migration of breast cancer cells, through actin cytoskeleton rearrangements. J Cell Biochem. 2011 Dec;112 (12) :3786-96. |[2]Bourgoin-Voillard S, et al. Calmodulin association with the synthetic ERα17p peptide investigated by mass spectrometry[J]. International Journal of Mass Spectrometry, 2011, 305 (2-3) : 87-94.|[3]Pelekanou V, et al., The estrogen receptor alpha-derived peptide ERα17p (P (295) -T (311) ) exerts pro-apoptotic actions in breast cancer cells in vitro and in vivo, independently from their ERα status. Mol Oncol. 2011 Feb;5 (1) :36-47.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported