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ER 50891

CAT: 0804-HY-108531-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108531-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis[1].
CAS Number
187400-85-7
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/er-50891.html
Purity
99.86
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(C2=CC=C(C3=NC4=C(C(C)C)C=CC=C4C(C5=CC=CC=C5)=C3)N2)C=C1
Molecular Formula
C29H24N2O2
Molecular Weight
432.51
References & Citations
[1]Wang S, et al. The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation. Drug Des Devel Ther. 2020 Jan 22;14:297-308.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RXRα

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