ER-DRI

• Description:

  ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi[1].

• UNSPSC:

  12352209

• Target:

  Enterovirus; Virus Protease

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  O=C ([C@H] (N) CCCNC (N) =N) N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N1[C@@H] (C (N2[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (N[C@@H] (C (NCC (N[C@@H] (C (O) =O) CC3=CC=C (O) C=C3) =O) =O) CCCNC (N) =N) =O) CCCCN) =O) CCCCN) =O) CCCNC (N) =N) =O) CCCNC (N) =N) =O) CCC (N) =O) =O) CCCNC (N) =N) =O) CCCNC (N) =N) =O) CCCNC (N) =N) =O) CCC2) =O) CCC1) =O) CCC (O) =O) =O) CCC (O) =O) =O) C (C) C) =O) CCCNC (N) =N) =O) CCC (N) =O) =O) CC4=CC=C (O) C=C4) =O) CS

• Molecular Formula:

  C118H201N49O30S

• Molecular Weight:

  2818.23

• References & Citations:

  [1]Fang Y, et al. Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo. Immunity. 2021 Oct 12;54 (10) :2231-2244.e6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported