ER-DRI

• Description :

  ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi[1].

• UNSPSC :

  12352209

• Target :

  Enterovirus; Virus Protease

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=C([C@H](N)CCCNC(N)=N)N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N1[C@@H](C(N2[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(NCC(N[C@@H](C(O)=O)CC3=CC=C(O)C=C3)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC2)=O)CCC1)=O)CCC(O)=O)=O)CCC(O)=O)=O)C(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC4=CC=C(O)C=C4)=O)CS

• Molecular Formula :

  C118H201N49O30S

• Molecular Weight :

  2818.23

• References & Citations :

  [1]Fang Y, et al. Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo. Immunity. 2021 Oct 12;54 (10) :2231-2244.e6.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported