Phrixotoxin-1 (TFA)

Phrixotoxin-1 (TFA)

• UNSPSC Description: Phrixotoxin-1 (TFA), from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel[1][2].
• Target Antigen: Potassium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/phrixotoxin-1-tfa.html
• Purity: 96.46
• Solubility: H2O : ≥ 100 mg/mL
• Smiles: OC1=CC=C(C[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@H]4[C@@H](C)O)=O)=O)CCSC)=O)CC5=CNC6=CC=CC=C56)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC7=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]8CC9=CNC%10=CC=CC=C9%10)=O)CC(C)C)=O)CCCNC(N)=N)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CC(O)=O)=O)NC4=O)=O)C(C)C)=O)CC(C)C)=O)=O)CCC(O)=O)=O)=O)N)C=C1.OC(C(F)(F)F)=O.[x]
• Molecular Weight: 3548.30 (free base)
• References & Citations: [1]Benjamin Chagot, et al. Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 2004, 13, 5.  |[2]Grit Schaarschmidt, et al. Characterization of Voltage-Gated Potassium Channels in Human Neural Progenitor Cells. PLoS One. 2009, 4, 7.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported