Phrixotoxin 3

• Description :

  Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].

• UNSPSC :

  12352209

• Target :

  Sodium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/phrixotoxin-3.html

• Solubility :

  H2O

• Smiles :

  O=C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@H]2C(C)C)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]7CC8=CNC9=CC=CC=C89)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CC(N)=O)C(N%10[C@@H](CCC%10)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC%11=CC=C(C=C%11)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)NC7=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

• Molecular Formula :

  C176H269N51O48S6

• Molecular Weight :

  4059.72

• References & Citations :

  [1]Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69 (2) : 419-29.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5

• CAS Number :

  [880886-00-0]