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HDAC11-IN-1 (TFA)

CAT: 0804-HY-173076A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173076A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC11-IN-1 (Compound 14-NC6OH) TFA is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. HDAC11-IN-1 TFA exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2[1].
UNSPSC
12352005
Target
HDAC; YAP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Purity
99.25
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(F)(C1=CC=CC=C1C[C@@H](C(N[C@@H]([C@H](CC)C)C(N[C@@H](CCCCCC(N(CCCCCC)O)=O)C(NCCCSC2)=O)=O)=O)NC(CCSCC3=CC=CC2=N3)=O)F.O=C(O)C(F)(F)F
Molecular Formula
C45H64F6N6O8S2
Molecular Weight
995.15
References & Citations
[1]Danková D, et al. Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11. JACS Au. 2025 Feb 16;5 (3) :1299-1307.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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