Phrixotoxin-1

• Description:

  Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel[1][2].

• UNSPSC:

  12352209

• Target:

  Potassium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/phrixotoxin-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C (C[C@@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@@H] (CC2=CNC3=CC=CC=C23) C (N[C@H]4[C@@H] (C) O) =O) =O) CCSC) =O) CC5=CNC6=CC=CC=C56) =O) CCCCN) =O) CCC (N) =O) =O) CSSC[C@H] (NC7=O) C (N[C@H] (C (NCC (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]8CC9=CNC%10=CC=CC=C9%10) =O) CC (C) C) =O) CCCNC (N) =N) =O) CSSC[C@@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]7CSSC[C@H] (NC8=O) C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@@H] ([C@H] (CC) C) C (N) =O) =O) [C@H] (CC) C) =O) CCCCN) =O) CCCCN) =O) =O) CCCCN) =O) CCCNC (N) =N) =O) C) =O) CO) =O) CC (O) =O) =O) NC4=O) =O) C (C) C) =O) CC (C) C) =O) =O) CCC (O) =O) =O) =O) N) C=C1

• Molecular Formula:

  C156H240N44O37S7

• Molecular Weight:

  3548.30

• References & Citations:

  [1]Benjamin Chagot, et al. Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 2004 May;13 (5) :1197-208.|[2]Grit Schaarschmidt, et al. Characterization of Voltage-Gated Potassium Channels in Human Neural Progenitor Cells. PLoS One. 2009 Jul 8;4 (7) :e6168.|[3]Ryota Imai, et al. Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3. Biosci Biotechnol Biochem. 2019 Feb;83 (2) :202-211.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  221872-97-5