Phrixotoxin-1

• UNSPSC Description:

  Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel[1][2].

• Target Antigen:

  Potassium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/phrixotoxin-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C(C[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@H]4[C@@H](C)O)=O)=O)CCSC)=O)CC5=CNC6=CC=CC=C56)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC7=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]8CC9=CNC%10=CC=CC=C9%10)=O)CC(C)C)=O)CCCNC(N)=N)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CC(O)=O)=O)NC4=O)=O)C(C)C)=O)CC(C)C)=O)=O)CCC(O)=O)=O)=O)N)C=C1

• Molecular Weight:

  3548.30

• References & Citations:

  [1]Benjamin Chagot, et al. Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 2004 May;13(5):1197-208.|[2]Grit Schaarschmidt, et al. Characterization of Voltage-Gated Potassium Channels in Human Neural Progenitor Cells. PLoS One. 2009 Jul 8;4(7):e6168.|[3]Ryota Imai, et al. Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3. Biosci Biotechnol Biochem. 2019 Feb;83(2):202-211.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  221872-97-5