TPP-1 (TFA)

• Description:

  TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (KD=95 nM) . TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function[1].

• UNSPSC:

  12352209

• Target:

  PD-1/PD-L1

• Type:

  Peptides

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tpp-1-tfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N1[C@@H] (CCC1) C (NCC (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CO) C (NCC (NCC (N[C@@H] (CO) C (N[C@H] (C (O) =O) CCCCN) =O) =O) =O) =O) =O) =O) =O) [C@H] (CC (O) =O) NC ([C@H] (CCCNC (N) =N) NC ([C@@H] (NC ([C@H] (CS) NC ([C@@H] (NC ([C@H] (CS) NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CO) NC ([C@H] (C) NC ([C@@H] (NC ([C@H] (CCC (N) =O) NC (CNC ([C@@H] (N) CO) =O) =O) =O) CC2=CC=C (C=C2) O) =O) =O) =O) CC3=CC=C (C=C3) O) =O) CC4=CN=CN4) =O) =O) CC5=CNC6=CC=CC=C56) =O) =O) CC7=CNC8=CC=CC=C78) =O) =O.O=C (C (F) (F) F) O

• Molecular Formula:

  C109H151F3N34O34S2

• Molecular Weight:

  2602.70

• References & Citations:

  [1]Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6 (2) :178-188.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported