SNIPER (ER) -87

• Description :

  SNIPER (ER) -87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM) . SNIPER (ER) -87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER (ER) -87-induced ERα degradation[1][2].

• CAS Number :

  [2222354-91-6]

• UNSPSC :

  12352005

• Target :

  Estrogen Receptor/ERR; SNIPERs

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sniper-er-87.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=CC(OCCOCCOCCOCC(N(C)CCOC5=CC=C(/C(C6=CC=C(O)C=C6)=C(C7=CC=CC=C7)\CC)C=C5)=O)=C4)=O)=CS3)CCC2)=O)=O

• Molecular Formula :

  C59H73N5O10S

• Molecular Weight :

  1044.30

• References & Citations :

  [1]Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP) -dependent Protein Erasers (SNIPERs) . J Biol Chem. 2017 Mar 17;292 (11) :4556-4570.|[2]Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293 (18) :6776-6790.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported