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SNIPER (ER) -87

CAT: 0804-HY-129619Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129619Size:5 mg
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Description
SNIPER (ER) -87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM) . SNIPER (ER) -87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER (ER) -87-induced ERα degradation[1][2].
CAS Number
2222354-91-6
UNSPSC
12352005
Target
Estrogen Receptor/ERR; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-er-87.html
Solubility
10 mM in DMSO
Smiles
C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=CC(OCCOCCOCCOCC(N(C)CCOC5=CC=C(/C(C6=CC=C(O)C=C6)=C(C7=CC=CC=C7)\CC)C=C5)=O)=C4)=O)=CS3)CCC2)=O)=O
Molecular Formula
C59H73N5O10S
Molecular Weight
1044.30
References & Citations
[1]Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP) -dependent Protein Erasers (SNIPERs) . J Biol Chem. 2017 Mar 17;292 (11) :4556-4570.|[2]Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293 (18) :6776-6790.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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