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SNIPER (ER) -110

CAT: 0804-HY-122825Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122825Size:1 Each
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Description
SNIPER (ER) -110 consists of a IAP ligand and an estrogen ligand, connected by a linker. SNIPER (ER) -51 induces estrogen receptor (ER) protein degradation with DC50s of [1].
CAS Number
2241690-03-7
UNSPSC
12352005
Target
Estrogen Receptor/ERR; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-er-110.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)C[C@@H](OC3=CC=CC(OCCOCCOCCOCC(N(C)CCOC4=CC=C(/C(C5=CC=C(O)C=C5)=C(C6=CC=CC=C6)/CC)C=C4)=O)=C3)C1)N[C@@H]7CCCC8=C7C=CC=C8
Molecular Formula
C66H83N5O11
Molecular Weight
1122.39
References & Citations
[1]Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293 (18) :6776-6790.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
T18696-01SNIPER (ER) -110
MBS5771555SNIPER(ER)-110
MBS3606946SNIPER (ER)-110
T18697SNIPER (ER) -87
7120/5SNIPER(ER)-87
BR1102Triple negative breast cancer (the most of TNBC) tissue array , including pathology grade, TNM, clinical stage (AJCC 8th edition) and IHC (ER/PR/Her-2) results, 110 cases/110 cores (core size 1.0mm)
BC081120gBreast cancer (including one case of male breast cancer) with adjacent normal breast tissue array, including pathology grade, TNM and clinical stage (AJCC 7th edition) with IHC results ER/PR/Her2/Ki67,110 cases/110 cores (core size 1.0 mm), replacing BC081120f
BC081116eBreast cancer with cancer adjacent breast tissue array, including invasive carcinoma of no special type , breast carcinoma with apocrine differentiation and AT tissue, pathology grade, IHC ( ER/PR/Her-2/Ki67) info, TNM/Stage ( AJCC 7th edition), 107 cases/110 cores ( core size 1.5mm), replacing BC081116d-BC081116e
XND35429-01SNIPER (ABL) -039
XND35418-01SNIPER (ABL) -033

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