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SNIPER (ABL) -013

CAT: 0804-HY-111860Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111860Size:1 Each
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Description
SNIPER (ABL) -013, conjugating GNF5 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 20 μM[1].
UNSPSC
12352005
Target
Bcr-Abl; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-abl-013.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC1=CC=CC=C1)N)=O)=O)C2=CC=CC(C3=NC=NC(NC4=CC=C(OC(F)(F)F)C=C4)=C3)=C2
Molecular Formula
C42H52F3N7O8
Molecular Weight
839.90
References & Citations
[1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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