SNIPER (ER) -87

CAT: 0931-T18697Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T18697Size:5 mg
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AVAILABILITY: InStock
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CAS Number
2222354-91-6
Target
SNIPERs|||Estrogen Receptor/ERR|||Others
Related Pathways
Endocrinology/Hormones|||Others|||PROTAC
Bioactivity
SNIPER (ER) -87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor ? (ER?) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ER? protein with an IC50 value of 0.097 ?M. Within cells, SNIPER (ER) -87 selectively recruits XIAP to ER?, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ER? induced by SNIPER (ER) -87[1][2].
Smiles
[H][C@]1(CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)c1nc(cs1)C(=O)c1cccc(OCCOCCOCCOCC(=O)N(C)CCOc2ccc(cc2)C(=C(CC)c2ccccc2)c2ccc(O)cc2)c1|w:58.61|
Molecular Formula
C59H73N5O10S
Molecular Weight
1044.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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