SNIPER (ER) -87

• Target:

  SNIPERs|||Estrogen Receptor/ERR|||Others

• Related Pathways:

  Endocrinology/Hormones|||Others|||PROTAC

• Bioactivity:

  SNIPER (ER) -87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor ? (ER?) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ER? protein with an IC50 value of 0.097 ?M. Within cells, SNIPER (ER) -87 selectively recruits XIAP to ER?, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ER? induced by SNIPER (ER) -87[1][2].

• Smiles:

  [H][C@]1(CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)c1nc(cs1)C(=O)c1cccc(OCCOCCOCCOCC(=O)N(C)CCOc2ccc(cc2)C(=C(CC)c2ccccc2)c2ccc(O)cc2)c1|w:58.61|

• Molecular Formula:

  C59H73N5O10S

• Molecular Weight:

  1044.32

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2222354-91-6