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SNIPER (BRD) -1

CAT: 0804-HY-111875-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111875-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNIPER (BRD) -1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER (BRD) -1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER (BRD) -1 can be used for cancer research[1]. (Blue: LCL161 ; Black: linker (HY-W008005) ; Pink: (+) -JQ-1 (HY-13030) )
CAS Number
2095244-54-3
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Epigenetic Reader Domain; PROTACs; SNIPERs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-brd-1.html
Purity
99.68
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5
Molecular Formula
C53H66ClN9O8S2
Molecular Weight
1056.73
Precautions
H302, H312, H332
References & Citations
[1]Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER) . Chem Pharm Bull (Tokyo) . 2019 Mar 1;67 (3) :203-209.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4

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