SNIPER (ER) -110

• Target:

  Others|||SNIPERs|||Estrogen Receptor/ERR

• Related Pathways:

  Endocrinology/Hormones|||Others|||PROTAC

• Bioactivity:

  SNIPER (ER) -110 comprises a cIAP1 ligand and an estrogen ligand connected by a linker. SNIPER (ER) -51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively [1].

• Smiles:

  O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@@H](NC)C)=O)=O)C[C@@H](OC3=CC=CC(OCCOCCOCCOCC(N(C)CCOC4=CC=C(/C(C5=CC=C(O)C=C5)=C(C6=CC=CC=C6)/CC)C=C4)=O)=C3)C1)N[C@@H]7CCCC8=C7C=CC=C8

• Molecular Formula:

  C66H83N5O11

• Molecular Weight:

  1122.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C