SNIPER (ER) -110

• Target:

  Others|||SNIPERs|||Estrogen Receptor/ERR

• Related Pathways:

  Endocrinology/Hormones|||Others|||PROTAC

• Bioactivity:

  SNIPER (ER) -110 comprises a cIAP1 ligand and an estrogen ligand connected by a linker. SNIPER (ER) -51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively [1].

• Smiles:

  O=C ([C@H]1N (C ([C@H] (C2CCCCC2) NC ([C@@H] (NC) C) =O) =O) C[C@@H] (OC3=CC=CC (OCCOCCOCCOCC (N (C) CCOC4=CC=C (/C (C5=CC=C (O) C=C5) =C (C6=CC=CC=C6) /CC) C=C4) =O) =C3) C1) N[C@@H]7CCCC8=C7C=CC=C8

• Molecular Formula:

  C66H83N5O11

• Molecular Weight:

  1122.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C