SNIPER(TACC3)-11

• UNSPSC Description:

  SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells[1].

• Target Antigen:

  FGFR; SNIPERs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sniper-tacc3-11.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CN[C@H](C(N[C@@H](C1CCCCC1)C(N2CCC[C@H]2C3=NC(C(C4=CC(OCCOCCOCCNC(C5=CC=C(C=C5)C6=NC(CNC7=NC=CC(NCC(C)C)=N7)=CS6)=O)=CC=C4)=O)=CS3)=O)=O)C

• Molecular Weight:

  995.26

• References & Citations:

  [1]Shibata N, Cho N, Koyama H, Naito M. Development of a degrader against oncogenic fusion protein FGFR3-TACC3. Bioorg Med Chem Lett. 2022;60:128584.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2906151-68-4