SNIPER (ABL) -024

CAT: 0931-T18688-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-T18688-01Size:100 mg
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CAS Number
2222355-77-1
Target
SNIPERs|||Others|||Bcr-Abl
Related Pathways
Cytoskeletal Signaling|||PROTAC|||Tyrosine Kinase/Adaptors|||Others|||Angiogenesis
Bioactivity
SNIPER (ABL) -024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 5?M[1].
Smiles
C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCCNC(=O)C5=CC(=CC=C5)C=6C=C(NC7=CC=C(OC(F)(F)F)C=C7)N=CN6)=CC=C4)=CS3)[H]
Molecular Formula
C52H61F3N8O9S
Molecular Weight
1031.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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