SNIPER (ABL) -044

• Description:

  SNIPER (ABL) -044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].

• UNSPSC:

  12352005

• Target:

  Bcr-Abl; SNIPERs

• Type:

  Reference compound

• Related Pathways:

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sniper-abl-044.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCN1CCN (CC2=C (C (F) (F) F) C=C (NC (C3=CC (C4=NC5=C (N=C (NC (COCCOCCOCCNC ([C@H] (CC (C) C) NC ([C@@H] (O) [C@@H] (CC6=CC=CC=C6) N) =O) =O) =O) S5) C=C4) =CC=C3) =O) C=C2) CC1

• Molecular Formula:

  C51H64F3N9O8S

• Molecular Weight:

  1020.17

• References & Citations:

  [1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported