SNIPER (ABL) -044

• Description :

  SNIPER (ABL) -044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].

• UNSPSC :

  12352005

• Target :

  Bcr-Abl; SNIPERs

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sniper-abl-044.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC6=CC=CC=C6)N)=O)=O)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1

• Molecular Formula :

  C51H64F3N9O8S

• Molecular Weight :

  1020.17

• References & Citations :

  [1]Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108 (8) :1657-1666.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported