TUG-905

• Description :

  TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].

• UNSPSC :

  12352005

• Target :

  Free Fatty Acid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tug-905.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(CCC1=CC=C(C=C1F)NCC2=CC(C3=CC=C(C=C3C)OCCCS(=O)(C)=O)=CC=C2)O

• Molecular Formula :

  C27H30FNO5S

• Molecular Weight :

  499.59

• References & Citations :

  [1]Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14 (1) :91.|[2]Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10 (1) :11047.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1390641-90-3]