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TUG-905

CAT: 0804-HY-117787Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117787Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].
CAS Number
[1390641-90-3]
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tug-905.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=CC=C(C=C1F)NCC2=CC(C3=CC=C(C=C3C)OCCCS(=O)(C)=O)=CC=C2)O
Molecular Formula
C27H30FNO5S
Molecular Weight
499.59
References & Citations
[1]Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14 (1) :91.|[2]Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10 (1) :11047.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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