TUG-1375

• Description:

  TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Free Fatty Acid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/TUG-1375.html

• Concentration:

  10mM

• Purity:

  99.42

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(N1[C@@H](C2=CC=CC=C2Cl)SC[C@H]1C(O)=O)C3=CC=C(C4=C(C)ON=C4C)C=C3

• Molecular Formula:

  C22H19ClN2O4S

• Molecular Weight:

  442.92

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61 (21) :9534-9550.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2247372-59-2]