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CST 905

CAT: 0931-T83933Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T83933Size:5 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others
Related Pathways
Others
Bioactivity
CST 905, a selective and potent BRAFV600EDegrader (PROTAC) with a DC50 of 18 nM, features a von Hippel Lindau (VHL) E3 ligase ligand connected via a linker to a PLX-derived ligand. Distinctively, CST 905 does not activate ERK, setting it apart from other BRAFV600EDegraders.
Smiles
FC1=C(C(F)=CC=C1NS(N(C)CC)(=O)=O)C(C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)N5CCN(CC5)CC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=O
Molecular Formula
C51H58F2N10O7S2
Molecular Weight
1025.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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