PRO-905

• UNSPSC Description:

  Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) [1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pro-905.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=S)=C3N=C2)O[C@@H]1COP(N[C@H](C(OC(C)C)=O)C)(OC4=CC=CC=C4)=O

• Molecular Weight:

  568.54

• References & Citations:

  [1]Lemberg KM,et al. Pro-905, a novel purine antimetabolite, combines with glutamine amidotransferase inhibition to suppress growth of malignant peripheral nerve sheath tumor. Mol Cancer Ther. 2023 Aug 24:MCT-23-0258.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2762209-68-5