TUG-2181

CAT: 0804-HY-176039Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176039Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TUG-2181 is an antagonist of GPR84 with an IC50 value of 34 nM. TUG-2181 inhibits GPR84 agonists-induced reactive species oxygen (ROS) production and IL-8 release in human neutrophils. TUG-2181 can be used for inflammation and fibrosis study[1].
CAS Number
[2653994-24-0]
UNSPSC
12352005
Target
GPR84; Reactive Oxygen Species (ROS)
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
OC1=CC(CCC2=CC=C(C=C2)OCC)=NC(OCC3CCCCO3)=C1
Molecular Formula
C21H27NO4
Molecular Weight
357.44
References & Citations
[1]Ieremias L, et al. Minimal Structural Variation of GPR84 Full Agonist Causes Functional Switch to Inverse Agonism. J Med Chem. 2025 Apr 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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