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Bcl-2-IN-20

CAT: 0804-HY-161786Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161786Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl-2-IN-20 (Compound 81) is an inhibitor for Bcl-2 with IC50 IC50>10 μM), A549 (IC50=6.1 μM), HepG2 (IC50>10 μM), MCF-7 (IC50=8.9 μM), HCT116 (IC50>10 μM) and HEK-293 (IC50=14.1 μM) . Bcl-2-IN-20 promotes the ROS production, induces apoptosis and DNA damage[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-20.html
Smiles
O=C(/C(S1)=C/C2=COC3=CC=C(Br)C=C3C2=O)N(CC(C4=CC=C(OC)C=C4)=O)C1=O
Molecular Formula
C22H14BrNO6S
Molecular Weight
500.32
References & Citations
[1]Galla MS, et al., Development of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents. Bioorg Med Chem Lett. 2024 Sep 1;109:129853.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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