Bcl-2-IN-2

Bcl-2-IN-2

• CAS Number: 2383085-86-5
• UNSPSC Description: Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/bcl-2-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NS(=O)(C1=CC=C(NC[C@H]2CC[C@@](O)(C)CC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCC5(CC(N6CCC[C@H]6C7=C(CC)C=CC=C7)C5)CC4)C=C3OC8=CC(C=CN9)=C9N=C8
• Molecular Weight: 876.07
• References & Citations: [1]Yunhang GUO, et al. Bcl-2 INHIBITORS. WO2019210828A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported