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Bcl-2-IN-2

CAT: 0804-HY-131247Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131247Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL[1].
CAS Number
2383085-86-5
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(C1=CC=C(NC[C@H]2CC[C@@](O)(C)CC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCC5(CC(N6CCC[C@H]6C7=C(CC)C=CC=C7)C5)CC4)C=C3OC8=CC(C=CN9)=C9N=C8
Molecular Formula
C48H57N7O7S
Molecular Weight
876.07
References & Citations
[1]Yunhang GUO, et al. Bcl-2 INHIBITORS. WO2019210828A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL

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