BCL-xL/BCL-2 ligand 1

BCL-xL/BCL-2 ligand 1

• CAS Number: 2941091-91-2
• UNSPSC Description: BCL-xL/BCL-2 ligand 1 (compound 72-1) is a BCL-xL and BCL-2 protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410)[1][2].
• Target Antigen: Ligands for E3 Ligase
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bcl-xl-bcl-2-ligand-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C[C@@](C)(C1)CCC(C2=CC=C(C=C2)Cl)=C1CN3CCN(C4=CC=C(C=C4)C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(C=C5)N[C@@H](CSC6=CC=CC=C6)CCN7[C@]8([H])C[C@](OC8)([H])C7)=O)=O)CC3
• Molecular Weight: 1000.61
• References & Citations: [1]Guangrong Zheng, et al. Bcl-xl/bcl-2 dual degraders for treatment of cancers. WO2023107606A1.|[2]Nayak D, et al. Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun. 2024 Mar 29;15(1):2743.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported