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Bcl-2-IN-11

CAT: 0804-HY-153953Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153953Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM) . Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].
CAS Number
2760536-88-5
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-11.html
Solubility
10 mM in DMSO
Smiles
O=S(NC(C(C=CC(N1C[C@H](N(CC1)CC2=C(C3=CC=C(C=C3)Cl)CC(C)(CC2)C)C)=C4)=C4OC5=CN=C(NC=C6)C6=C5)=O)(C7=CC([N+]([O-])=O)=C(C(F)=C7)NC[C@H]8COCCO8)=O
Molecular Formula
C45H49ClFN7O8S
Molecular Weight
902.43
References & Citations
[1]Kong Xianglong, et al. Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL

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