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Bcl-2-IN-9

CAT: 0804-HY-149009Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149009Size:1 Each
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Description
Bcl-2-IN-9 is a novel proapoptotic Bcl-2 inhibitor with IC50 value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells[1].
CAS Number
2490542-33-9
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-9.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=NC3=CC=CC=C3N=C2SC4=NN=C(C5=CC=C(OCCN6CCOCC6)C=C5)O4)CC1
Molecular Formula
C27H31N7O3S
Molecular Weight
533.65
References & Citations
[1]Yukari Ono, et al. Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein. Bioorg Chem. 2020 Aug; 104: 104245.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2

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