Bcl-2-IN-4

• Description:

  Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM) . Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2) [1].

• UNSPSC:

  12352005

• Target:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bcl-2-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NS(=O)(C1=C2C(N=CN2)=C(NCC3CCOCC3)C([N+]([O-])=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CC(C)(C)CC6)CC5)C=C4OC8=CN=C(NC=C9)C9=C8

• Molecular Formula:

  C46H50ClN9O7S

• Molecular Weight:

  908.46

• References & Citations:

  [1]Hongjian Wang, et al. Benzo five-membered cyclic compound. WO2021180040A1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bcl-2; Bcl-xL

• CAS Number:

  [2703134-40-9]