Bcl-2-IN-4

Bcl-2-IN-4

• CAS Number: 2703134-40-9
• UNSPSC Description: Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2)[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bcl-2-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NS(=O)(C1=C2C(N=CN2)=C(NCC3CCOCC3)C([N+]([O-])=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CC(C)(C)CC6)CC5)C=C4OC8=CN=C(NC=C9)C9=C8
• Molecular Weight: 908.46
• References & Citations: [1]Hongjian Wang, et al. Benzo five-membered cyclic compound. WO2021180040A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported