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ZG-2305

CAT: 0804-HY-168533-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168533-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZG-2305 is a potent, orally active and selective factor inhibiting hypoxia-inducible factor (FIH) inhibitor with Ki values of 79.6, 2786 nM for FIH, PHD2, respectively. ZG-2305 increases the expression of EGLN3 gene. ZG-2305 decreases the cellular triglycerides levels and reduces lipid accumulation. ZG-2305 has the potential for the research of obesity and fatty liver disease[1].
CAS Number
2962103-54-2
UNSPSC
12352101
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/zg-2305.html
Smiles
OC(CNC(C1=NC=C(C=C1O)C2=CC(C3=CC(Cl)=CC(Cl)=C3)=NO2)=O)=O
Molecular Formula
C17H11Cl2N3O5
Molecular Weight
408.19
References & Citations
[1]Wu Y, et al. Discovery of ZG-2305, an Orally Bioavailable Factor Inhibiting HIF Inhibitor for the Treatment of Obesity and Fatty Liver Disease. J Med Chem. 2024 Oct 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3-Hydroxy-5-(3-m-dichlorophenylisoxazol-5-yl)picolinoyl glycine
CAS Number2962103-54-2
PubChem CID170066338
IUPAC Name2-[[5-[3-(3,5-dichlorophenyl)-1,2-oxazol-5-yl]-3-hydroxypyridine-2-carbonyl]amino]acetic acid
Molecular FormulaC17H11Cl2N3O5
Molecular Weight408.2
XLogP3.3
Topological Polar Surface Area126
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity545
SMILES
C1=C(C=C(C=C1Cl)Cl)C2=NOC(=C2)C3=CC(=C(N=C3)C(=O)NCC(=O)O)O
InChI
InChI=1S/C17H11Cl2N3O5/c18-10-1-8(2-11(19)4-10)12-5-14(27-22-12)9-3-13(23)16(20-6-9)17(26)21-7-15(24)25/h1-6,23H,7H2,(H,21,26)(H,24,25)
InChIKey
IVVBSKSURSLYFK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Hydroxy-5-(3-m-dichlorophenylisoxazol-5-yl)picolinoyl glycine
CAS: 2962103-54-2
CID: 170066338
Formula: C17H11Cl2N3O5
MW: 408.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight408.2
XLogP33.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass407.0075758
Monoisotopic Mass407.0075758
Topological Polar Surface Area126 Ų
Heavy Atom Count27
Formal Charge0
Complexity545
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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