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ZG-2686

CAT: 0013-GTR19273786-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273786-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZG-2686 is a potent and selective agonist of HIF-2α with an EC50 of 0.25 μM, demonstrating selectivity for PHD2. It binds to a specific internal cavity of HIF-2α, forming hydrogen bonds through structural water molecules, which stabilizes the HIF-2α/β heterodimer and enhances its transcriptional activity. The compound acts synergistically with Vadadustat to upregulate HIF-2α-dependent EPO gene expression both in vitro and in vivo. ZG-2686 is applicable for renal anemia research.
CAS Number
1795110-22-3
Smiles
O=C (NC1=NNC=2N=CC=CC21) C3=CC=C (Br) C=C3
Molecular Formula
C13H9BrN4O
Molecular Weight
317.15
Storage Conditions
-20°C
Notes
For research use only.

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