Products for Research Use Only
RegisterLogin

ZG-126

CAT: 0804-HY-161778Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-161778Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM) . ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization[1].
CAS Number
3049802-32-3
UNSPSC
12352005
Target
HDAC; VD/VDR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zg-126.html
Smiles
CCC(CC)(C1=CC=C(C=C1)C(NCCCCC(NO)=O)=O)C2=NC(C)=C(C=C2)OCC(C(C)(C)C)O
Molecular Formula
C29H43N3O5
Molecular Weight
513.67
References & Citations
[1]Sarmadi F, et al., Bifunctionality and Antitumor Efficacy of ZG-126, a Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Hybrid Molecule. J Med Chem. 2024 Jun 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8

Related Products

CatalogName
HY-139855-01ZG-2033
HY-168533-01ZG-2305
HY-179647ZG-2686
HY-159120-01ZG-2291
HY-175230ZG-2492
HY-112894ZG-10
HY-163271XL-126
HY-162964EGFR-IN-126
HY-P0305-01PrP (106-126)
HY-P5321-01BFGF (119-126)

Alternative Products

CatalogName
T210292-01ZG-126
FZ166274-01ZG-10
T200939-01ZG-2305
GTR19264143-01ZG-2492
T203229-01ZG-2033
GTR19238138-01ZG-2291
GTR19273786-01ZG-2686
MBS5802118Antibiotic ZG 1494alpha
301401MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126)
301401-PEMAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126) (PE)

Popular Products