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ZG-126

CAT: 0931-T210292-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210292-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3049802-32-3
Target
Vitamin, HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Metabolism
Bioactivity
ZG-126 is an agonist of the vitamin D receptor (VDR) and an inhibitor of histone deacetylase (HDAC) with an IC50 range of 0.63-67.6 μM. It demonstrates cytotoxicity in cancer cell lines MDA-MB-231 and 4T1. In mouse models, ZG-126 exhibits antitumor and antimetastatic effects against melanoma and triple-negative breast cancer (TNBC) . Additionally, it shows anti-inflammatory activity by reducing macrophage infiltration and polarization to the immunosuppressive M2 subtype.
Smiles
O=C(NCCCCC(=O)NO)C1=CC=C(C=C1)C(C=2N=C(C(OCC(O)C(C)(C)C)=CC2)C)(CC)CC
Molecular Formula
C29H43N3O5
Molecular Weight
513.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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301401MAP126 (MAP-126, Microtubule-Associated Protein 126, MAP 126)
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