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ZG-10

CAT: 0804-HY-112894Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112894Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent[1][2].
CAS Number
1408077-04-2
UNSPSC
12352005
Target
JNK; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zg-10.html
Smiles
O=C(NC1=CC=C(C(NC2=CC(NC3=NC(C4=CN=CC=C4)=CC=N3)=CC=C2)=O)C=C1)/C=C/CN(C)C
Molecular Formula
C28H27N7O2
Molecular Weight
493.56
References & Citations
[1]Tinghu Zhang, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19 (1) :140-54.|[2]Rui Zhang, et al. Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium. Bioengineered. 2022 Feb;13 (2) :2486-2497.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3

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