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OX2-2303

CAT: 0804-HY-178871Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178871Size:1 Each
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Description
OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research[1].
CAS Number
1607428-33-0
Target
Orexin Receptor (OX Receptor)
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC1=CC(C(N2C[C@H](OC3=NC=CC(C#N)=C3C)CC[C@H]2C)=O)=C(C4=NC=CS4)C=C1
Molecular Formula
C23H21FN4O2S
Molecular Weight
436.50
References & Citations
[1]1. Rong J, et al. Development of Novel 18F‑Labeled Selective Orexin‑2 Receptor Radioligands for Positron Emission Tomography. ACS Pharmacol. Transl. Sci. 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
OX2 Receptor

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