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Y502-2304

CAT: 0804-HY-178909Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178909Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Y502-2304 is a c-Myc G-quadruplex stabilizer. Y502-2304 exhibits potent antiproliferative activity in multiple myeloma (MM) cells. Y502–2304 downregulates c-Myc mRNA and protein expression. Y502-2304 induces apoptosis in MM cells, characterizes by elevated γH2AX levels, increases reactive oxygen species (ROS) generation, and mitochondrial dysfunction. Y502-2304 significantly inhibits tumor growth in a xenograft MM model. Y502-2304 can be used for the study of multiple myeloma[1].
CAS Number
741278-95-5
UNSPSC
12352005
Target
Apoptosis; c-Myc; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
CC1=C(C(OC)=O)SC2=C1C3=NC(C4=CC=C([N+]([O-])=O)C=C4)=NN3C=N2
Molecular Formula
C16H11N5O4S
Molecular Weight
369.35
References & Citations
[1]Gao J, et al. Discovery of Y502-2304, a potent c-Myc G-quadruplex stabilizer for the treatment of multiple myeloma. Eur J Med Chem. 2026 Jan 5;301:118209.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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