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ZG-2033

CAT: 0804-HY-139855-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139855-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZG-2033 (Compound 26) is an orally active HIF-2α agonist that demonstrates nanomolar activity in luciferase reporter gene assays (EC50 = 490 nM). ZG-2033 has the effect of alleviating anemia and exhibits synergistic action with AKB-6548 in anemia, and can be used in the study of renal anemia[1].
CAS Number
2685739-28-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/zg-2033.html
Smiles
COC1=CC(OC)=CC(NC2=NSC3=CC=CC=C23)=C1
Molecular Formula
C15H14N2O2S
Molecular Weight
286.35
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Yu Y, et al. Discovery of a potent and orally bioavailable hypoxia-inducible factor 2α (HIF-2α) agonist and its synergistic therapy with prolyl hydroxylase inhibitors for the treatment of renal anemia[J]. Journal of Medicinal Chemistry, 2021, 64 (23) : 17384-17402.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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