PROTAC STING Degrader-2

• UNSPSC Description:

  PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferon genes (STING) (DC50=0.53 μM). PROTAC STING Degrader-2 is combined with STING protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of STING protein. PROTAC STING Degrader-2 can be used to investigate the role of STING in autoinflammation and autoimmune diseases (PINK: STING binder (HY-145009); Blue: VHL ligand (HY-164043); Black: linker)[1][2].

• Target Antigen:

  PROTACs; STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Others

• Assay Protocol:

  https://www.medchemexpress.com/protac-sting-degrader-2-1.html

• Smiles:

  CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCNC(C4=CC=CC(S(=O)(N5C=C(C=CC5=O)C(NCCCCCC(OC6=C(C=C(C=C6)NC(C7=CC=C(C=C7)C8=CC=CC=C8)=O)NS(=O)(C9=CC=C(C=C9)F)=O)=O)=O)=O)=C4)=O)=O)=O)=O)O)=O)C

• Molecular Weight:

  1463.67

• References & Citations:

  [1]Luo Q, et al. Covalent PROTAC design method based on a sulfonyl pyridone probe[J]. Chemical Communications, 2024, 60(6): 686-689.|[2]Nakamura M, et al. Development of STING degrader with double covalent ligands[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129677.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3023095-61-3