PROTAC STING Degrader-2

PROTAC STING Degrader-2

• CAS Number: 3023095-61-3
• UNSPSC Description: PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferon genes (STING) (DC50=0.53 μM). PROTAC STING Degrader-2 is combined with STING protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of STING protein. PROTAC STING Degrader-2 can be used to investigate the role of STING in autoinflammation and autoimmune diseases (PINK: STING binder (HY-145009); Blue: VHL ligand (HY-164043); Black: linker)[1][2].
• Target Antigen: PROTACs; STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Others
• Assay Protocol: https://www.medchemexpress.com/protac-sting-degrader-2-1.html
• Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCNC(C4=CC=CC(S(=O)(N5C=C(C=CC5=O)C(NCCCCCC(OC6=C(C=C(C=C6)NC(C7=CC=C(C=C7)C8=CC=CC=C8)=O)NS(=O)(C9=CC=C(C=C9)F)=O)=O)=O)=O)=C4)=O)=O)=O)=O)O)=O)C
• Molecular Weight: 1463.67
• References & Citations: [1]Luo Q, et al. Covalent PROTAC design method based on a sulfonyl pyridone probe[J]. Chemical Communications, 2024, 60(6): 686-689.|[2]Nakamura M, et al. Development of STING degrader with double covalent ligands[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129677.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported