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PROTAC STING Degrader-2

CAT: 0804-HY-158036Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158036Size:1 Each
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Description
PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferon genes (STING) (DC50=0.53 μM). PROTAC STING Degrader-2 is combined with STING protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of STING protein. PROTAC STING Degrader-2 can be used to investigate the role of STING in autoinflammation and autoimmune diseases (PINK: STING binder ; Blue: VHL ligand (HY-164043) ; Black: linker)[2].
CAS Number
3023095-61-3
UNSPSC
12352005
Target
PROTACs; STING
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/protac-sting-degrader-2-1.html
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCC(NCCCNC(C4=CC=CC(S(=O)(N5C=C(C=CC5=O)C(NCCCCCC(OC6=C(C=C(C=C6)NC(C7=CC=C(C=C7)C8=CC=CC=C8)=O)NS(=O)(C9=CC=C(C=C9)F)=O)=O)=O)=O)=C4)=O)=O)=O)=O)O)=O)C
Molecular Formula
C74H79FN10O15S3
Molecular Weight
1463.67
References & Citations
[1]Luo Q, et al. Covalent PROTAC design method based on a sulfonyl pyridone probe[J]. Chemical Communications, 2024, 60 (6) : 686-689.|[2]Nakamura M, et al. Development of STING degrader with double covalent ligands[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129677.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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