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PROTAC STING degrader-4

CAT: 0931-T207609-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207609-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
IκB/IKK, PROTACs, NF-κB, STING
Related Pathways
PROTAC, Immunology/Inflammation, NF-κB
Bioactivity
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI) .
Molecular Formula
C39H42Cl2N8O9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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