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PROTAC ERα Degrader-2

CAT: 0931-T18605-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T18605-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1351169-29-3
Target
PROTACs, SNIPERs, Estrogen Receptor/ERR
Related Pathways
PROTAC, Endocrinology/Hormones
Bioactivity
PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs) [1].
Smiles
C[C@@]1\2[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC/C2=N\OCC(NCCOCCOCCNC([C@@H](NC([C@H]([C@@H](CC5=CC=CC=C5)N)O)=O)CC(C)C)=O)=O)[H]
Molecular Formula
C42H61N5O8
Molecular Weight
763.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C