Products for Research Use Only
RegisterLogin

PROTAC STING degrader-4

CAT: 0804-HY-176180Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-176180Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PROTAC STING degrader-4 is a nitro-free covalent STING PROTAC degrader with a DC50 of 3.23 μM. PROTAC STING degrader-4 effectively inhibits STING as well as its downstream signaling, such as p-TBK1 and p-NF-κB (p-P65), and immune-inflammatory cytokines. PROTAC STING degrader-4 mitigates kidney and blood inflammation in Cisplatin -induced acute kidney injury (AKI) mice model[1]. Pink: STING ligand (HY-176183) ; Blue: CRBN ligase ligand (HY-103596) ; Black: linker (HY-176182) ; CRBN ligase ligand + linker: HY-176181
UNSPSC
12352005
Target
IKK; NF-κB; PROTACs; STING
Related Pathways
Immunology/Inflammation; NF-κB; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
ClC(C=C(C=N1)NC(NC2=CNC3=CC=C(C=C32)Cl)=O)=C1N(CC4)CCN4CCOCCOCCOCCOC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O
Molecular Formula
C39H42Cl2N8O9
Molecular Weight
837.70
References & Citations
[1]An Y, et al. Discovery of indole derivatives as STING degraders. Eur J Med Chem. 2025 May 12; 294:117747.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB; TBK1

Related Products

CatalogName
HY-158036PROTAC STING Degrader-2
HY-173414-01PROTAC STING degrader-3
HY-150608-01PROTAC STING Degrader-1
HY-128408PROTAC BTK Degrader-4
HY-178796PROTAC LRRK2 Degrader-4
HY-174086PROTAC GPX4 degrader-4
HY-111848PROTAC AR Degrader-4
HY-128843PROTAC MDM2 Degrader-4
HY-179732PROTAC ALK degrader-4
HY-179166PROTAC sEH-degrader-4

Alternative Products

CatalogName
T207609-01PROTAC STING degrader-4
MBS5816830PROTAC STING Degrader-1
GTR19258238-01PROTAC STING degrader-3
T88066-01PROTAC STING Degrader-2
TBI5001-5MGSTING Degrader 1, STING degrader
JFC27550-01PROTAC cIAP1 degrader-4
T205547-01PROTAC HDAC6 degrader 4
T74515-01PROTAC EGFR degrader 4
T39901-01PROTAC IRAK4 degrader-4
T13839-01PROTAC ER Degrader-4

Popular Products