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PROTAC STING degrader-3

CAT: 0804-HY-173414-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173414-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC STING degrader-3 (Compound ST9) is a STING PROTAC degrader (DC50: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI) (Pink: STING ligand ; Blue: E3 ligase CRBN ligand (HY-41547) ; Black: linker).
UNSPSC
12352005
Target
NF-κB; PROTACs; STING
Related Pathways
Immunology/Inflammation; NF-κB; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
98.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(NC(/C=C/C(N3CCN(CC4CN(C5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)CC3)=O)=O)C=C2
Molecular Formula
C37H36N8O10
Molecular Weight
752.73
References & Citations
[1]Ma R, et al. Discovery of novel rigid STING PROTAC degraders as potential therapeutics for acute kidney injury. Eur J Med Chem. 2025 Jun 5;290:117539.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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