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PROTAC STING Degrader-2

CAT: 0931-T88066-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88066-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3023095-61-3
Target
PROTACs, STING
Related Pathways
PROTAC, Immunology/Inflammation
Bioactivity
PROTAC STING Degrader-2 is a protein degrader targeting the Stimulator of interferon genes (STING) with a DC50 of 0.53 μM. It induces STING protein degradation by covalently binding to both the STING protein and an E3 ubiquitin ligase. This compound is useful for studying the role of STING in autoinflammatory and autoimmune diseases.
Smiles
C([C@@H](NC(CCC(NCCCNC(=O)C1=CC(S(=O)(=O)N2C=C(C(NCCCCCC(OC3=C(NS(=O)(=O)C4=CC=C(F)C=C4)C=C(NC(=O)C5=CC=C(C=C5)C6=CC=CC=C6)C=C3)=O)=O)C=CC2=O)=CC=C1)=O)=O)[C@@](C)(C)C)(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C=9SC=NC9C)=O)C[C@@H](O)C7
Molecular Formula
C74H79FN10O15S3
Molecular Weight
1463.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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