NMS-P626

• Description :

  NMS-P626 is an inhibitor of TRKA, TRKB, and TRKC, with IC50 values of 8 nM, 7 nM, and 3 nM, respectively. NMS-P626 inhibits the growth of KM12 cells by suppressing the phosphorylation of TPM3-TRKA and downstream signaling in KM12 cells, with an IC50 of 19 nM for KM12 cells. NMS-P626 can be used in colorectal cancer research[1].

• UNSPSC :

  12352005

• Target :

  Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nms-p626.html

• Smiles :

  O=C(C1=C(N[C@@H](COC)C)C=C(N2CCN(C)CC2)C=C1)NC3=NNC4=C3CN(S(C5=CC(F)=CC(F)=C5)(=O)=O)CC4

• Molecular Formula :

  C28H35F2N7O4S

• Molecular Weight :

  603.68

• References & Citations :

  [1]Ardini E, et al. The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition. Mol Oncol. 2014 Dec;8 (8) :1495-507.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TrkA; TrkB; TrkC

• CAS Number :

  [942471-37-6]