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NMS-P626

CAT: 0804-HY-164514Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164514Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NMS-P626 is an inhibitor of TRKA, TRKB, and TRKC, with IC50 values of 8 nM, 7 nM, and 3 nM, respectively. NMS-P626 inhibits the growth of KM12 cells by suppressing the phosphorylation of TPM3-TRKA and downstream signaling in KM12 cells, with an IC50 of 19 nM for KM12 cells. NMS-P626 can be used in colorectal cancer research[1].
CAS Number
942471-37-6
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nms-p626.html
Smiles
O=C(C1=C(N[C@@H](COC)C)C=C(N2CCN(C)CC2)C=C1)NC3=NNC4=C3CN(S(C5=CC(F)=CC(F)=C5)(=O)=O)CC4
Molecular Formula
C28H35F2N7O4S
Molecular Weight
603.68
References & Citations
[1]Ardini E, et al. The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition. Mol Oncol. 2014 Dec;8 (8) :1495-507.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB; TrkC

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