NMS-P626

• Target:

  Trk receptor

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Bioactivity:

  NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.

• Smiles:

  N(C(=O)C1=C(N[C@@H](COC)C)C=C(C=C1)N2CCN(C)CC2)C=3C4=C(NN3)CCN(S(=O)(=O)C5=CC(F)=CC(F)=C5)C4

• Molecular Formula:

  C28H35F2N7O4S

• Molecular Weight:

  603.68

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  942471-37-6