NMS-P626

CAT: 0931-MF-0142446-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0142446-01Size:25 mg
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CAS Number
942471-37-6
Target
Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
NMS-P626 functions as an inhibitor targeting TRKA, TRKB, and TRKC, exhibiting IC 50 values of 8 nM, 7 nM, and 3 nM respectively. It effectively suppresses KM12 cell growth by inhibiting the phosphorylation of TPM3-TRKA and the subsequent downstream signaling, demonstrating an IC 50 of 19 nM specifically for KM12 cells. This compound is applicable in the study of colorectal cancer.
Smiles
N(C(=O)C1=C(N[C@@H](COC)C)C=C(C=C1)N2CCN(C)CC2)C=3C4=C(NN3)CCN(S(=O)(=O)C5=CC(F)=CC(F)=C5)C4
Molecular Formula
C28H35F2N7O4S
Molecular Weight
603.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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