NMS-859

CAT: 0804-HY-15714-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15714-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
CAS Number
[1449236-96-7]
UNSPSC
12352005
Hazard Statement
H302, H314
Target
P97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NMS-859.html
Purity
98.05
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S1(C2=CC=CC=C2C(NC3=CC(NC(CCl)=O)=CC=C3)=N1)=O
Molecular Formula
C15H12ClN3O3S
Molecular Weight
349.79
Precautions
H302, H314
References & Citations
[1]Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9 (9) :548-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
MBS3846388-01NMS-859
A21965-1NMS-859 1mg
A21965-100NMS-859 100mg
A21965-5NMS-859 5mg
A21965-10NMS-859 10mg
A21965-25NMS-859 25mg
A21965-500NMS-859 500mg
A21965-2NMS-859 2mg
A21965-50NMS-859 50mg
bs-60148C-01NMS-859 --- ATPase VCP/p97 Inhibitor

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