NMS-859

• Description:

  NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H314

• Target:

  P97

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/NMS-859.html

• Purity:

  98.05

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=S1(C2=CC=CC=C2C(NC3=CC(NC(CCl)=O)=CC=C3)=N1)=O

• Molecular Formula:

  C15H12ClN3O3S

• Molecular Weight:

  349.79

• Precautions:

  H302, H314

• References & Citations:

  [1]Magnaghi P, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Sep;9 (9) :548-56.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1449236-96-7]