NMS-873

• UNSPSC Description:

  NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM.

• Target Antigen:

  p97

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/NMS-873.html

• Solubility:

  DMSO : 20.5 mg/mL (ultrasonic;warming)

• Smiles:

  CC(C=C(OCC1=NN=C(SC2CCCC2)N1C3=CC=CN=C3)C=C4)=C4C5=CC=C(S(=O)(C)=O)C=C5

• Molecular Weight:

  520.67

• References & Citations:

  [1]Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1418013-75-8