NMS-873

• Description :

  NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with an IC50 value of 30 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  P97

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/NMS-873.html

• Purity :

  99.92

• Solubility :

  DMSO : 20.5 mg/mL (ultrasonic; warming)

• Smiles :

  CC(C=C(OCC1=NN=C(SC2CCCC2)N1C3=CC=CN=C3)C=C4)=C4C5=CC=C(S(=O)(C)=O)C=C5

• Molecular Formula :

  C27H28N4O3S2

• Molecular Weight :

  520.67

• Precautions :

  H302

• References & Citations :

  [1]Paola Magnaghi, et al. Covalent and allosteric inhibitors of the ATPATP ase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013 Jul 28. doi: 10.1038/nchembio.1313.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1418013-75-8]