NMS-E973

CAT: 0804-HY-17547-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17547-01Size:5 mg
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AVAILABILITY: InStock
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Description
NMS-E973 is a potent and selective inhibitor of HSP90. NMS-E973 binds to the ATP binding site of Hsp90α with a DC50 of [1].
CAS Number
[1253584-84-7]
UNSPSC
12352005
Hazard Statement
H302, H400, H410
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nms-e973.html
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=NOC(C2=C(OC3=CC=C([N+]([O-])=O)C=C3)C=C(O)C=C2O)=C1)NC4CCN(C)CC4
Molecular Formula
C22H22N4O7
Molecular Weight
454.43
Precautions
H302, H400, H410
References & Citations
[1]Gianpaolo Fogliatto, et al. NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases. Clin Cancer Res. 2013 Jul 1;19 (13) :3520-32.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

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