NMS-P515

• Description :

  NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells) . Anti-tumor activity[1].

• UNSPSC :

  12352005

• Target :

  PARP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nms-p515.html

• Purity :

  98.18

• Solubility :

  DMSO : 3.33 mg/mL (ultrasonic)

• Smiles :

  O=C(N)C1=C2C([C@H](C)N(C3CCN(C4CCCCC4)CC3)C2=O)=CC=C1

• Molecular Formula :

  C21H29N3O2

• Molecular Weight :

  355.47

• References & Citations :

  [1]Papeo G, et al. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. ACS Med Chem Lett. 2019 Mar 13;10 (4) :534-538.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PARP1

• CAS Number :

  [1262395-13-0]