NMS-P515

• Description:

  NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells) . Anti-tumor activity[1].

• UNSPSC:

  12352005

• Target:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nms-p515.html

• Purity:

  98.18

• Solubility:

  DMSO : 3.33 mg/mL (ultrasonic)

• Smiles:

  O=C(N)C1=C2C([C@H](C)N(C3CCN(C4CCCCC4)CC3)C2=O)=CC=C1

• Molecular Formula:

  C21H29N3O2

• Molecular Weight:

  355.47

• References & Citations:

  [1]Papeo G, et al. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. ACS Med Chem Lett. 2019 Mar 13;10 (4) :534-538.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PARP1

• CAS Number:

  [1262395-13-0]