NMS-P645

CAT: 0804-HY-117744Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117744Size:1 Each
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Description
NMS-P645 is a PIM1 inhibitor. NMS-P645 exhibits anti-proliferative activity when combined with GDC-0941 (HY-50094) in TMPRSS2/ERG positive and negative PCa cells. NMS-P645 can reverse PIM1-induced pro-survival signals in prostate cells. NMS-P645 can be studied in research on prostate cancer[1].
CAS Number
[1482518-95-5]
UNSPSC
12352005
Target
Pim
Related Pathways
JAK/STAT Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Smiles
O=C(N[C@@H](C1CCCCC1)CN2CCN(C)CC2)C[C@H]3CNC(C4=CC(C5=CC=CC(Cl)=C5)=CN43)=O
Molecular Formula
C28H38ClN5O2
Molecular Weight
512.09
References & Citations
[1]Mologni, L., et al., (2017) . The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition. Journal of Cancer, 8 (1), 140-145.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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