NMS-0963

CAT: 0804-HY-162427Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-162427Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC50 value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM[1].

CAS Number

2765304-82-1

UNSPSC

12352005

Target

Syk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/nms-0963.html

Solubility

10 mM in DMSO

Smiles

CN1C(C(N[C@@H](C)CN2CCC2)=O)=CC(C3=CC=NC(NC4=CC(OC)=CC(OC)=C4)=N3)=N1

Molecular Formula

C23H29N7O3

Molecular Weight

451.52

References & Citations

[1]Giovanni Cervi, et al. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur J Med Chem. 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Related Products

Catalog	Name
HY-106363	MK-0963
HY-171805	PSB-0963
HY-15713-01	NMS-873
HY-156249	NMS-P528
HY-129679	NMS-P953
HY-117744	NMS-P645
HY-18954-01	NMS-P118
HY-164514	NMS-P626
HY-156299	NMS-P945
HY-17547-01	NMS-E973

Alternative Products

Catalog	Name
T87026-01	NMS-0963
T29254-01	MK-0963
T211796-01	PSB-0963
302602	NMS (Neuromedin-S, NMS)
MBS130280-01	NMS-1286937, NMS-P937
402647-01	NMS
MBS6457695-01	NMS (Neuromedin-S, NMS) (HRP)
MBS6457694-01	NMS (Neuromedin-S, NMS) (FITC)
MBS6457691-01	NMS (Neuromedin-S, NMS) (AP)
326078	NMS (Neuromedin-S, NMS) discontinued

NMS-0963

Related Products

Alternative Products

Popular Products